Somatic mutations in chromatin remodeler genes could modify the epigenomic landscape of CLL, but They can be unheard of in this malignancy when compared to other lymphoid neoplasms. CHD2 is mutated in five% of CLL and seven% of MBL.seventy five The histone methyltransferase SETD2 and ARID1A can also be mutated in a small proportion of patients. Of